Table 1.
Daytime and nighttime hemodynamic data of sham-operated and 2K1C mice fed 0.1% or 4.0% NaCl diet at baseline or at days 7 and 20
| Daytime |
Nighttime |
|||||
|---|---|---|---|---|---|---|
| Baseline | Day 7 | Day 20 | Baseline | Day 7 | Day 20 | |
| 0.1% NaCl [n = 8 (daytime) and 8 (nighttime)] | ||||||
| Mean ABP, mmHg | 97 ± 4 | 125 ± 6* | 124 ± 11* | 107 ± 3 | 140 ± 5* | 138 ± 8* |
| ΔMean ABP, mmHg | 0 ± 3 | 30 ± 8* | 18 ± 11* | 0 ± 5 | 34 ± 7* | 24 ± 11* |
| Systolic ABP, mmHg | 119 ± 5 | 152 ± 6* | 152 ± 11* | 131 ± 4 | 171 ± 4* | 170 ± 8* |
| Diastolic ABP, mmHg | 85 ± 4 | 112 ± 7* | 110 ± 10* | 94 ± 3 | 125 ± 6* | 122 ± 9* |
| Heart rate, beats/min | 553 ± 38 | 526 ± 35 | 523 ± 36 | 614 ± 33 | 594 ± 31 | 585 ± 22 |
| Pulse pressure | 34 ± 1 | 40 ± 1* | 42 ± 1* | 37 ± 1 | 46 ± 2* | 49 ± 1* |
| ΔPulse pressure | 0 ± 1 | 6 ± 4* | 5 ± 4* | 0 ± 2 | 9 ± 4* | 8 ± 3* |
| 4.0% NaCl [n = 8 (daytime) and 8 (nighttime)] | ||||||
| Mean ABP, mmHg | 93 ± 4 | 136 ± 10*# | 121 ± 18* | 109 ± 9 | 150 ± 7*# | 137 ± 11* |
| ΔMean ABP, mmHg | 0 ± 4 | 44 ± 11*# | 26 ± 6* | 0 ± 4 | 43 ± 6*# | 25 ± 11* |
| Systolic ABP, mmHg | 115 ± 5 | 165 ± 10*# | 154 ± 20* | 131 ± 4 | 182 ± 7*# | 174 ± 13* |
| Diastolic ABP, mmHg | 82 ± 3 | 121 ± 10* | 105 ± 15 | 98 ± 11 | 133 ± 7*# | 119 ± 10* |
| Heart rate, beats/min | 512 ± 14 | 517 ± 27 | 507 ± 23 | 598 ± 15 | 588 ± 30 | 562 ± 34 |
| Pulse pressure | 33.8 ± 0.7 | 44.5 ± 0.7* | 49.4 ± 1.9*# | 33.7 ± 3.1 | 49.0 ± 0.7* | 54.8 ± 1.5*# |
| ΔPulse pressure | 0 ± 2 | 11 ± 2* | 13 ± 8*# | 0 ± 8 | 15 ± 8* | 14 ± 7*# |
Values are means ± SD for 2-kidney, 1-clip (2K1C) and sham-operated mice. ABP, arterial blood pressure. Two-way ANOVA and Bonferroni post hoc test performed for significance.
*
P < 0.05 from baseline;
#
P < 0.05 between groups.