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T-box transcription factor 5 (TBX5) and miR-19 in Holt Oram syndrome. Downregulation of the TBX5 gene negatively affects expression of miR-19a and causes cardiac and fin defects in a zebrafish model of Holt Oram syndrome. Replacement of miR-19a partially rescued the cardiac and fin defects observed due to downregulation of the TBX5 gene.
