Fig. 3.

Long noncoding RNAs (lncRNAs) influence chromatin state and gene expression. lncRNAs recruitment and association with a histone (blue) tail (yellow) modifying enzyme that deposits repressive histone 3 trimethylation of lysine 27 marks (H3K27me3; red), resulting in chromatin compaction (A), or deposits activating histone 3 trimethylation of lysine 4 marks (H3K4me3; green; B). C: presence of a lncRNA acting as a competing endogenous RNA (ceRNA) binding factor, which can sponge microRNAs (miRNAs) and increase translation of miRNA targets. MLL, mixed-lineage leukemia; PRC2, polycomb repressor 2 complex.