Table 1.
Associations between the subjects’ demographics and APOE E4 and E2 variants
| Subject demographics (no is given if less than 140) |
APOE-E4 Present (no 55) |
APOE-E4 Absent (no 85) |
Statistics p-value |
Adjusted* p-value |
APOE-E2 Present (no 18) |
APOE-E2 Absent (no 122) |
Statistics p-value |
Adjusted* p-value |
|---|---|---|---|---|---|---|---|---|
| Gender (female) | 43/55 (78%) | 65/85 (76%) | p = 0.84 | 13/18 (72%) | 95/122 (78%) | 0.76 | ||
| Age (years) | 42.6 (9.5) | 43.3 (8.1) | P = 0.68 | 41.8 (8.4) | 43.2 (8.7) | 0.53 | ||
| Body weight (kg) | 124.5 (19.3) | 123.3 (18.4) | P = 0.72 | 126.2 (20.7) | 123.4 (18.4) | 0.56 | ||
| Height (cm) | 171.6 (9.6) | 170.7 (8.5) | P = 0.59 | 172.2 (9.2) | 170.9 (8.9) | 0.58 | ||
| BMI (kg / m2) | 42.1 (4.0) | 42.1 (3.7) | P = 0.99 |
−0.07 (−1.26;1.13) p = 0.91 ** |
42.4 (4.9) | 42.1 (3.6) | 0.73 |
0.00 (− 1.74; 1.74) p = 1.00 ** |
| BMI reduction during the first treatment period (no 95) | 3.2 (1.6) | 2.9 (1.5) | P = 0.28 |
0.34 (−0.21; 0.98) p = 0.30 |
2.7 (1.4) | 3.1 (1.6) | 0.48 |
−0.28 (−1.22;0.66) P = 0.56 |
| BMI reduction during the last treatment period (no 92) | 11.0 (3.7) | 10.5 (3.2) | P = 0.46 |
0.94 (−0.37;2.25) p = 0.16 |
10.0 (4.5) | 10.8 (3.2) | 0.44 |
−0.41 (−2.30;1.48) p = 0.67 |
| BMI reduction total (no 92) | 14.3 (3.8) | 13.4 (3.5) | P = 0.21 |
1.36 (−0.04;2.75) p = 0.057 |
12.7 (5.1) | 13.9 (3.3) | 0.45 |
−0.72 (−2.76;1.32) p = 0.49 |
The results are given as mean (SD) or number (proportion). Chi-square and T-test were used for the comparisons. *Adjusted associations between the subject demographics (dependent variable) and APOE E4 and E2 variants were analysed with linear regression analyses adjusted for age, gender and BMI and reported as unstandardized coefficients (B-value) with 95% confidence intervals and p-values. ** Adjusted for age and gender