Table 2.
Associations between comorbidity and APOE E4 and E2 variants
| Subjects’ psychosomatic disorders (no is given if less than 140) |
APOE-E4 Present (no 55) |
APOE-E4 Absent (no 85) |
Statistics p-value |
Adjusted* p-value |
APOE-E2 Present (no 18) |
APOE-E2 Absent (no 122) |
Statistics p-value |
Adjusted* p-value |
|---|---|---|---|---|---|---|---|---|
| Diabetes (no 135) | 12/54 (22%) | 14/81 (17%) | p = 0.51 |
OR† 0.30 (0.55;3.33) p = 0.51 |
6/18 (33%) | 20/117 (17%) | 0.12 |
OR† 0.92 (0.77;8.1) p = 0.12 |
| Hypertension (no 135) | 19/54 (35%) | 27/81 (33%) | p = 0.85 |
OR† 0.11 (0.051;2.48) p = 0.78 |
10/18 (56%) | 36/117 (31%) | 0.06 |
OR† 1.34 (1.21;12.1) p = 0.022 |
| Physical activity (no 134) | 4.5 (2.3) | 4.5 (2.2) | p = 0.84 | - 0.076 (−0.868;0.715) p = 0.85 | 5.1 (1.6) | 4.4 (2.3) | 0.15 | 0.666 (−0.465;1.798) p = 0.25 |
| Musculoskeletal pain (no 137) | 4.5 (3.0) | 4.2 (2.9) | p = 0.66 |
−0.21 (− 0.81;1.23) p = 0.68 |
2.8 (2.5) | 4.5 (3.0) | 0.020 | −1.74 (−3.23;-0.26) p = 0.022 |
| WHO-5 Well-Being Index (no139) | 58.2 (18.5) | 59.8 (17.1) | p = 0.61 |
−1.60 (−7.73;4.52) p = 0.61 |
70.4 (14.1) | 57.5 (17.5) | 0.003 | 12.89 (4.22;21.56) p = 0.004 |
| Hopkins Symptom Checklist 10 (no 135) | 0.62 (0.57) | 0.57 (0.53) | p = 0.58 |
0.06 (−0.13;0.25) p = 0.54 |
0.27 (0.32) | 0.64 (0.56) | < 0.001 | −0.36 (− 0.62;-0.09) p = 0.009 |
| Rosenberg Self-Esteem (no 131) | 24.7 (1.9) | 24.3 (1.8) | p = 0.24 |
0.37 (−0.29;1.02) p = 0.27 |
25.2 (1.6) | 24.3 (1.9) | 0.057 | 0..87 (−0.08;1.81) p = 0.07 |
| Fatigue Severity Scale (no 137) | 36.6 (15.2) | 35.2 (14.6) | p = 0.61 |
1.34 (−3.75;6.43) p = 0.52 |
29.2 (13.3) | 36.7 (14.8) | 0.045 | −6.95 (− 14.22;0.32) p = 0.06 |
| Epworth Sleepiness Scale (no138) | 8.9 (5.1) | 7.4 (4.3) | p = 0.06 |
1.52 (−0.09;3.12) p = 0.06 |
6.0 (2.1) | 8.3 (4.9) | 0.052 | −2.22 (− 4.54;0.11) p = 0.06 |
| Sense of humour (no 138) | 19.6 (2.5) | 18.9 (2.8) | p = 0.12 |
−0.71 (− 0.19;1.60) p = 0.12 |
18.9 (2.5) | 19.2 (2.7) | 0.70 | −0.36 (−1.67;0.96) p = 0.60 |
The results are given as mean (SD) or number (proportion). Chi-square and t-test were used for the comparisons. *Adjusted associations between the subjects’ psychosomatic disorders (dependent variable) and APOE E4 and E2 were analysed with linear and logistic regression analyses adjusted for age, gender and BMI. The results are reported as unstandardized coefficients (B-value) or †Odds Ratio (OR) with 95% confidence intervals and p-values