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. 2020 Jul 8;12:60. doi: 10.1186/s13073-020-00754-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Genomic locations of CpG sites associated with differential inflammatory protein levels. The x-axis represents the chromosomal location of CpG sites associated with the levels of Olink® inflammation biomarkers. The y-axis represents the position of the gene encoding the associated protein. The level of concordance across three models used to perform epigenome-wide association studies is represented by different shape patterns. Those CpG sites (n = 3) which were identified by linear (ordinary least squares), mixed model and Bayesian penalised regression models, and passed a Bonferroni-corrected significance threshold are represented by diamonds and annotated. Three proteins (CXCL9, CXCL10 and CXCL11) were associated with differential methylation levels at the cg07839457 site in the NLRC5 transcription factor locus. Additionally, two proteins (CCL11 and TGF-alpha) were associated with the smoking-associated cg05575921 site in the AHRR locus. Cis (red); trans (blue)