Table 3.
Influence of glucose-6-phosphate dehydrogenase on P. falciparum malaria infection in children under 3 years in Vihiga County, Kenya
| Category | Prevalence (%) | SMA n = 137 |
Non-SMA n = 437 |
P-Valuea | OR | 95% CI | P-Valueb |
|---|---|---|---|---|---|---|---|
| G6PD deficiency | SMA | ||||||
| Normal | 360 (62.7) | 77 (56.2) | 283 (64.8) | 0.040 | Ref | – | – |
| Intermediate | 201 (35.0) | 59 (43.1) | 142 (32.5) | 1.527 | 1.029–2.266 | 0.035 | |
| Deficient | 13 (2.3) | 1 (0.7) | 12 (2.7) | 0.306 | 0.039–2.392 | 0.259 | |
Prevalence in the G6PD genotypes in population studied are presented as n (percentage, %). Data shown are number (n) and proportions (%) of subjects. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined using multivariate logistic regression controlling for age and sex. Non-severe malaria anaemia was used as the reference category. G6PD, glucose-6-phosphate dehydrogenase. Normal, normal G6PD. Intermediate, heterozygous G6PD. Deficient, homozygous G6PD. SMA, severe malaria aneamia; Non-SMA, non-severe malaria anaemia