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. 2020 Jul 8;20:294. doi: 10.1186/s12935-020-01334-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The expression of TMPO-AS1 is significantly upregulated in TC tissues and cells and facilitates TC cellular processes. a TMPO-AS1 expression was upregulated in TC tissues from TCGA database. b QRT-PCR assay was utilized to detect the expression of TMPO-AS1 in TC cell lines (A-PTC, CUTC5, TPC-1 and IHH-4) and human normal thyroid epithelial cell line (Nthy-ori3-1). c The knockdown efficiency of TMPO-AS1 was assessed by QRT-PCR assay in TPC-1 and IHH-4 cells transfected with sh-TMPO-AS1#1/2 or sh-NC. d, e The proliferation ability of transfected cells was measured by EdU assays and colony formation assay. f, g TUNEL and cytometry analysis was conducted to evaluate cell apoptosis rate in transfected cells. h, i Migration and invasion were examined in different groups in transwell assays. **p < 0.01