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. 2020 Jul 8;20:294. doi: 10.1186/s12935-020-01334-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — TMPO-AS1 positively regulates TMPO in TC. a The location of TMPO-AS1 in chromatin was displayed. b TMPO was upregulated in TC tissues from TCGA database. c There was a positive correlation between TMPO-AS1 and TMPO from GEPIA database. d The expression of TMPO in TC cell lines and human normal thyroid epithelial cell line was detected by QRT-PCR. e QRT-PCR was performed to examine the mRNA expression of TMPO in transfected cells. f Luciferase reporter assay was used to detect the interaction between TMPO-AS1 and TMPO promoter. g It was tested by FISH and subcellular fractionation assays that TMPO-AS1 mainly located in cytoplasm. h RIP assays demonstrated TMPO-AS1 and TMPO were enriched in Ago2 antibody. *p < 0.05, **p < 0.01