Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 8;20:294. doi: 10.1186/s12935-020-01334-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — MiR-498 is downregulated and negatively regulated by TMPO-AS1 as well as represses the growth of TC. a Target genes that could bind with TMPO-AS1 were obtained from starBase and DIANA tools database. b RNA pull down assays selected out miRNAs to bind with TMPO-AS1. c MiR-498 had a binding site for TMPO-AS1. d MiR-498 had a binding site for TMPO. e The expression of miR-498 in TC cell lines and human normal thyroid epithelial cell line was detected by QRT-PCR. f QRT-PCR was used to examine the expression of TMPO in TPC-1 and IHH-4 cells transfected with NC mimics or miR-498 mimics. g QRT-PCR assays were applied to measure the mRNA expression of TMPO in transfected cells. h–m The effects of miR-498 on TC growth were assessed by functional assays. **p < 0.01