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Schematic illustration of potential acute and chronic exercise-induced modulations of the KYN pathway and possible consequences for the immune system and central nervous system. CNS indicates central nervous system; HK, hydroxykynurenine; IDO, isoenzymes indoleamine; KA, kynurenic acid; KMO, kynurenine 3-monooxygenase; KYN, kynurenine; QA, quinolinic acid; TDO, tryptophan 2,3 dioxygenases; TRP, tryptophan.
