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. 2020 Jul 2;11:969. doi: 10.3389/fphar.2020.00969

Table 1.

Human leukocyte antigen (HLA) association between drugs and severe cutaneous adverse reactions (SCARs)/hypersensitivity in different ethnicity.

Drug HLA allele SCAR Ethnicity Negative predicted value (NPV) Positive predicted value (PPV)
Abacavir B*57:01 HSS Caucasian, Asians (Hetherington et al., 2002; Mallal et al., 2002; Mallal et al., 2008), Black (Saag et al., 2008) 100% in Caucasians 55% in Caucasians
Allopurinol B*58:01 SJS
TEN
DRESS
Han Chinese (Hung et al., 2005; Cao et al., 2012)
Thai (Tassaneeyakul et al., 2009)
Japanese (Kaniwa et al., 2008)
Korean (Kang et al., 2011)
European (Stamp et al., 2016)
100% in Han Chinese; 100% in Thai 2% in Han Chinese; 1.52% in Thai
Carbamazepine B*15:02 SJS
TEN
Han Chinese (Chung et al., 2004; Man et al., 2007)
Thai (Locharernkul et al., 2008; Tangamornsuksan et al., 2013)
Indian (Mehta et al., 2009)
Malaysian (Chang et al., 2011)
Vietnam (Nguyen et al., 2015)
Singapore (Chong et al., 2014)
Hong Kong (Kwan et al., 2014)
100% in Han Chinese, East Asian 3% in Han Chinese, East Asian
B*15:11 SJS
TEN
Koreans (Kim et al., 2011)
Japanese (Kaniwa et al., 2010)
B*57:01 SJS
TEN
European (Mockenhaupt et al., 2019) 99.98% in European 0.89% in European
A*31:01 DRESS
MPE
Han Chinese (Hung et al., 2006)
Korea (Kim et al., 2011)
Japanese (Ozeki et al., 2011)
Caucasians (Hung et al., 2006; McCormack et al., 2011)
99.97% in Han Chinese 0.59% in Han Chinese
Oxcarbazepine B*15:02 SJS
TEN
Han Chinese (Hung et al., 2010) 99.97% in Han Chinese 0.73% in Han Chinese
Dapsone B*13:01 DRESS Han Chinese (Zhang et al., 2013) 99.8% in Han Chinese, East Asian 7.8% in Han Chinese
Phenytoin B*15:02
B*13:01
B*51:01
SJS
TEN
Han Chinese (Hung et al., 2010; Cheung et al., 2013)
Thai (Locharernkul et al., 2008)
Malaysians (Chang et al., 2017)
Nevirapine DRB1*01:01 DRESS Hispanics, African (Martin et al., 2005)
Beta-lactam antibiotics C*04:06, C*08:01, DRB1*04:06 Delayed type hypersensitivity reactions (MPE, DRESS, and SJS Chinese (Singvijarn et al., 2019)
Flucloxacillin B*57:01
B*57:03
DILI Caucasian (Daly et al., 2009)
Britons, Swedish (Nicoletti et al., 2019b)
Amoxicillin-clavulanate DRB1*15:01-DRB5*01:01-DQB1*06:02 DILI Caucasian (Donaldson et al., 2010; Lucena et al., 2011)
HHS Vulnerability Disclosure