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. 2020 Jul 9;182(1):7–9. doi: 10.1016/j.cell.2020.06.017

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© 2020 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Multifaceted Blueprint for Monoclonal Antibody Discovery and Development

Rapid response to identify a protective monoclonal antibody is enabled by a combination of technological advances, matched with B cell selection criteria. High-throughput sequencing, B cell selection, and signature sequence panning identified thousands of SARS-CoV-2 reactive monoclonal antibodies, including a subset with ng/ul neutralization and protective capability, enabling rapid advancement to a phase I clinical trial.