TABLE 2.

Correlation matrix of AD biomarkers in a cohort of adults with DS

Biomarker		Aβ40	Aβ42	tau	p‐tau	NfL	sTREM2	YKL‐40	αSyn	Ng	SNAP‐25	VILIP‐1
Age	ρ	−0.13	−0.47	0.29	0.55	0.60	0.29	0.64	0.24	0.30	0.32	0.43
	P	n.s.	<.01	.055	<.001	<.0001	.060	<.0001	n.s.	<.05	<.05	<.01
Aβ40	ρ		0.63	0.21	0.29	−0.05	0.42	0.31	0.76	0.60	0.41	0.52
	P		<.0001	n.s.	.058	n.s.	<.01	.053	<.0001	<.0001	<.01	<.001
Aβ42	ρ			−0.32	−0.44	−0.49	0.08	−0.27	0.14	−0.04	−0.16	−0.11
	P			<.05	<.01	<.001	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
tau	ρ				0.72	0.74	0.31	0.55	0.54	0.61	0.57	0.56
	P				<.0001	<.0001	<.05	<.001	<.001	<.0001	<.0001	<.001
p‐tau	ρ					0.71	0.47	0.79	0.73	0.83	0.70	0.83
	P					<.0001	<.01	<.0001	<.0001	<.0001	<.0001	<.0001
NfL	ρ						0.44	0.59	0.38	0.48	0.45	0.42
	P						<.01	<.001	<.05	<.01	<.01	<.01
sTREM2	ρ							0.54	0.56	0.58	0.32	0.43
	P							<.001	<.001	<.001	<.05	<.01
YKL‐40	ρ								0.68	0.73	0.56	0.77
	P								<.0001	<.0001	<.001	<.0001
αSyn	ρ									0.93	0.61	0.82
	P									<.0001	<.0001	<.0001
Ng	ρ										0.65	0.84
	P										<.0001	<.0001
SNAP‐25	ρ											0.75
	P											<.0001

Correlation coefficients represent Spearman rho (ρ). P values <.05 were considered statistically significant. White cells are not significant (n.s.). Lightest gray are significant with P ≤ .06; light gray are significant with P < .05; medium gray are significant with P < .01; dark gray are significant with P < .001; darkest gray are significant with P < .0001.