Table 1.
Baseline characteristics of study populations.
| Study characteristics | Partners Healthcare Biobank (N = 13,667) |
Penn Medicine Biobank (N = 9,070) |
Mt. Sinai BioMe Biobank (N = 24,371) |
|---|---|---|---|
| Age | 60 (17) | 68 (14) | 57 (18) |
| Female gender, n (%) | 7,523 (55.0%) | 3,711 (41.0%) | 13,961 (57.3%) |
| Genetic ancestry | |||
| African (AFR) | 867 (6.3%) | 1927 (21.2%) | 6,979 (28.6%) |
| Ad Mixed American (AMR) | 799 (5.9%) | ----- | 7,048 (28.9%) |
| East Asian (EAS) | 167 (1.2%) | ----- | ----- |
| European (EUR) | 11,725 (85.8%) | 7143 (78.8%) | 10,344 (42.4%) |
| South Asian (SAS) | 109 (0.8%) | ----- | ----- |
| Body mass index, kg/m2 | 31.5 (8.3) | 29.3 (6.8) | 28.3 (6.9) |
| Systolic blood pressure, mmHg | 127 (16) | 126 (19) | 127 (20) |
| Smoking status, ever, n (%) | 4,807 (35.2%) | 4,366 (48.1%) | 4,251 (17.4%) |
| Hypertension, n (%) | 7,272 (46.9%) | 6,632 (73.1%) | 9,322 (38.3%) |
| Diabetes Mellitus, n (%) | 2,966 (21.7%) | 2,868 (31.6%) | 5,204 (21.4%) |
| Coronary Artery Disease, n (%) | 3,538 (25.9%) | 4,658 (51.4%) | 2,824 (11.6%) |
| Peripheral Artery Disease, n (%) | 1,427 (10.4%) | 1,736 (19.1%) | 1,679 (6.9%) |
| Cerebrovascular disease, n (%) | 1,439 (10.5%) | 649 (7.2%) | 862 (3.5%) |
| Total Cholesterol, mg/dL | 177 (42) | 175 (40) | 179 (45) |
| LDL-C, mg/dL | 97 (34) | 99 (33) | 100 (37) |
| HDL-C, mg/dL | 56 (19) | 50 (16) | 57 (23) |
| Triglycerides, mg/dL | 120 (65) | 141 (83) | 144 (77) |
Values are presented as mean (standard deviation) unless otherwise noted. Abbreviations: HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol.