Fig. 3.

NuRD is required to maintain a stable pluripotency state in hiPSCs A) MDS plot made from RNA-seq data of wild type, MBD3-KO and Rescued hiPSCs across a neural differentiation timecourse. Each point represents a biological replicate, and shapes indicate the days of differentiation. B) Heat map of genes found to be differentially expressed between WT and MBD3-KO cells in self-renewing conditions (day 0; FDR 5%). C) GO terms associated with genes significantly activated (open bars) or repressed (filled bars) in MBD3-KO cells relative to WT hiPSCs in self-renewing conditions.