Fig. 5.

NuRD facilitates an appropriate transcriptional response in mEpiSCs. A) An outline of the experiment, as in Fig. 4. B) Phase contrast images of wild type or Mbd3-KO mEpiSCs in self-renewing conditions. C) MDS plot of gene expression data collected across the neural differentiation time course, as in Fig. 3A. D) Heat map of DEG (FDR 1%) separated into four clusters by K-means clustering. E) Mean expression and most significant GO terms for each cluster as in Fig. 4B. A full list of GO terms and pathways is available in Tables S6 and S7. Gene expression changes during neural differentiation of an independent pair of WT and Mbd3-KO EpiSCs, verifying the results of the RNA-seq shown here, is displayed in Fig. S4.