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. Author manuscript; available in PMC: 2020 Jul 10.
Published in final edited form as: Science. 2020 Apr 17;368(6488):eaba0712. doi: 10.1126/science.aba0712

Figure 4. Local fragmentation accompanies mechanical bridge breakage and does not require TREX1.

Figure 4.

(A) Mechanical bridge breakage produces simple breaks and local fragmentation. Left: schematic of the experiment. Cells were collected immediately after mechanical bridge breakage to determine its direct consequences (i.e. not allowing time to generate chromosomal rearrangements). Right: Copy number plots, as in Fig. 3, show examples of simple bridge breakage (top) and local fragmentation (bottom).

(B) Copy number and SV plots, in Fig. 3: simple bridge breakage (top) and local fragmentation (bottom) after spontaneous bridge breakage in TREX1-null cells.