Table 2. Significant associations between HOMER1 rs3822568 polymorphism genotypes and theta (4–7.9 Hz) spectral power in sleep electroencephalogram.
Results are shown by derivation and sleep stage.
| Derivation | Sleep Stage | rs3822568 Genotype | df | F | p-value | Adjusted p-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | ||||||||||||
| N | Mean | SD | N | Mean | SD | N | Mean | SD | ||||||
| O2-A1 | 1 | 173 | 4.34 | 1.25 | 351 | 4.49 | 1.23 | 231 | 4.19 | 1.15 | 2,752 | 4.412 | 0.012 | 0.035 a |
| 2 | 188 | 4.24 | 1.18 | 384 | 4.42 | 1.24 | 245 | 4.17 | 1.16 | 2,814 | 3.679 | 0.026 | 0.086 | |
| REM | 187 | 4.09 | 1.20 | 382 | 4.15 | 1.10 | 243 | 3.87 | 1.08 | 2,809 | 4.847 | 0.008 | 0.029 b | |
| O1-A2 | 1 | 173 | 4.48 | 1.14 | 351 | 4.52 | 1.21 | 231 | 4.25 | 1.19 | 2,752 | 3.769 | 0.024 | 0.062 |
| REM | 187 | 4.29 | 1.15 | 382 | 4.24 | 1.09 | 243 | 3.97 | 1.10 | 2,809 | 5.59 | 0.004 | 0.008 c | |
| C3-A2 | 1 | 173 | 3.92 | 1.17 | 351 | 3.95 | 1.11 | 231 | 3.70 | 1.03 | 2,752 | 3.925 | 0.020 | 0.089 |
| 2 | 188 | 3.30 | 1.03 | 384 | 3.40 | 1.04 | 245 | 3.16 | 0.94 | 2,814 | 4.4 | 0.013 | 0.074 | |
| REM | 187 | 4.00 | 1.06 | 382 | 4.02 | 1.03 | 243 | 3.80 | 1.02 | 2,809 | 3.826 | 0.022 | 0.077 | |
| C4-A1 | REM | 187 | 3.84 | 1.01 | 382 | 3.86 | 1.04 | 243 | 3.63 | 1.00 | 2.809 | 4.09 | 0.017 | 0.073 |
One-Way ANOVA on z-score standardized measurements; SD: standard deviation; df: degrees of freedom (between groups, within groups); Adjusted p-value by sex, age, BMI and European ancestry proportion in general linear models.
a Bonferroni post hoc test for AG x GG: p = 0.041
b Bonferroni post hoc test for AG x GG: p = 0.023
c Bonferroni post hoc test for AA x GG: p = 0.018; for AG x GG: p = 0.020