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. 2020 Jul 9;15(7):e0232507. doi: 10.1371/journal.pone.0232507

Fig 2. Prolonged administration of isoproterenol causes similar cardiac dysfunction in male and female mice.

Fig 2

Male and female C57Bl/6NCrl mice were subcutaneously injected with 10 mg/kg isoproterenol (ISO) (male, female n = 12) or saline (male, female n = 7) daily for 14 days. (A-F) Cardiac function was assessed by trans-thoracic echocardiography. (A) Representative images from parasternal short axis view of the heart acquired in M-Mode. Effects of ISO on (B) ejection fraction, (C) fractional shortening, (D) LV volume in end-systole, (E) LV volume in end-diastole, (F) cardiac output, and (G) LV mass. (H) Heart weight to tibial length ratio. Values are shown as means ± SEM. *p<0.05, compared to control treatment of the same sex; # p<0.05, compared to male of same treatment by two-way ANOVA with Tukey’s post-hoc analysis.