Skip to main content
. 2020 Jul 9;15(7):e0232507. doi: 10.1371/journal.pone.0232507

Fig 7. Prolonged administration of isoproterenol causes similar cardiac dysfunction in ovariectomized (OVX) or sham-operated (SHAM) female mice.

Fig 7

(A-F) Cardiac function in adult female ovariectomized (OVX) (n = 3) and sham-operated (n = 4) C57Bl/6NCrl mice was assessed by trans-thoracic echocardiography one week prior to treatment (Pre-ISO), and again after 2 weeks of daily subcutaneous injections of 10 mg/kg isoproterenol (Post-ISO). (A) Representative images from parasternal short axis view of the heart acquired in M-Mode. Effects of ISO on (B) ejection fraction, (C) fractional shortening, (D) LV volume in end-systole, (E) LV volume in end-diastole, (F) cardiac output, and (G) LV mass. *p<0.05, compared to before treatment of the same surgical status by matched two-way ANOVA with Sidak’s post-hoc analysis.