. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: Cell Biochem Biophys. 2020 May 22;78(2):165–180. doi: 10.1007/s12013-020-00913-6

Table 1.

Gene Set Enrichment Analysis for signalling associated with mitochondrial metabolism based on microarray data obtained after 24 h of in vitro incubation of primary human epidermal keratinocytes with 1,25(OH)₂D3 or 20,23(OH)₂D3.

Gene Set Enrichment Analysis for 1,25(OH)₂D3					Gene Set Enrichment Analysis for 20,23(OH)₂D3
Reactome Pathway	Normalized Enriched Score	P-value	FDR	Direction	Normalized Enriched Score	P-value	FDR	Direction
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins	−1.368	0.068	0.258	Down	−3.195	0.00	3.496	Down
Respiratory electron transport	−1.352	0.091	0.270	Down	−3.095	0.00	6.049	Down
Fatty acyl-CoA biosynthesis	−0.720	0.745	0.871	Down	−1.980	0.035	0.029	Down
Glucose metabolism	−1.842	0.00	0.037	Down	−3.081	0.00	6.189	Down
Glycolysis	−2.000	0.00	0.016	Down	−2.726	0.016	0.012	Down
Mitochondrial calcium ion transport	−1.343	0.077	0.277	Down	−2.527	0.00	0.014	Down
Glucagon signaling in metabolic regulation	−1.837	0.00	0.038	Down
Digestion and absorption	−0.676	0.886	0.904	Down
Mitochondrial Fatty Acid Beta-Oxidation	1.207	0.224	0.455	Up	−2.051	0.00	0.024	Down
Citric acid cycle (TCA cycle)	0.948	0.480	0.693	Up	−2.354	0.00	0.015	Down
Pyruvate metabolism and Citric Acid (TCA) cycle	1.044	0.333	0.597	Up	−2.441	0.00	0.014	Down
Pyruvate metabolism	0.621	0.913	0.927	Up	−1.916	0.039	0.035	Down
Glycogen breakdown (glycogenolysis)	2.290	0.00	0.146	Up
Glycogen metabolism					−2.271	0.020	0.017	Down
Glycogen synthesis					−2.335	0.00	0.015	Down
Mitochondrial protein import					1.559	0.071	0.158	Up
Mitochondrial biogenesis					−1.462	0.089	0.139	Down
Fatty acid metabolism					−2.817	0.00	0.012	Down
Peroxisomal lipid metabolism					−2.432	0.00	0.014	Down