. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: Cell Biochem Biophys. 2020 May 22;78(2):165–180. doi: 10.1007/s12013-020-00913-6

Table 2.

Gene Set Enrichment Analysis (GSEA) for signalling connected with DNA repair and oxidative stress based on microarray data obtained after 24 h of in vitro incubation of primary human epidermal keratinocytes with 1,25(OH)₂D3 or 20,23(OH)₂D3.

Gene Set Enrichment Analysis for 1,25(OH)₂D3					Gene Set Enrichment Analysis for 20,23(OH)₂D3
Reactome Pathway	Normalized Enriched Score	P-value	FDR	Direction	Normalized Enriched Score	P-value	FDR	Direction
Oxidative Stress Induced Senescence	−1.931	0.00	0.024	Down	−2.509	0.00	0.013	Down
SUMOylation of DNA damage response and repair proteins	−3.236	0.00	0.00	Down	−2.213	0.00	0.018	Down
Cellular response to heat stress	−2.889	0.00	1.616	Down
DNA Damage/Telomere Stress Induced Senescence	−1.382	0.140	0.249	Down
TNF receptor superfamily (TNFSF) members mediating noncanonical NF-kB pathway	−1.231	0.245	0.356	Down
TNFR2 noncanonical NF-kB pathway					−1.999	0.020	0.028	Down
TRAF6 mediated NF-kB activation	−1.362	0.174	0.262	Down
FCERI mediated NF-kB activation					−2.604	0.00	0.014	Down
NIK-noncanonical NF-kB signaling	−2.761	0.00	0.012	Down
Interferon gamma signaling	−1.890	0.00	0.030	Down	−2.706	0.00	0.013	Down
Interferon Signaling	−3.851	0.00	0.00	Down	−2.706	0.00	0.013	Down
Interleukin-20 family signaling	−1.591	0.022	0.118	Down
Interleukin-1 signaling					−1.888	0.016	0.038	Down
Interleukin-1 family signaling					−1.796	0.035	0.050	Down
Inflammasomes	−1.593	0.057	0.117	Down
Interleukin-12 signaling					−1.773	0.043	0.054	Down
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha					−2.626	0.00	0.013	Down
AURKA Activation by TPX2	−2.409	0.00	1.876	Down
Regulation of Hypoxia-inducible Factor (HIF) by oxygen					−2.275	0.021	0.017	Down
Arachidonic acid metabolism					−2.245	0.00	0.018	Down
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.838	0.686	0.768	Up	2.115	0.00	0.062	Up
TP53 Regulates Metabolic Genes	1.392	0.102	0.307	Up
TP53 Regulates Transcription of Cell Cycle Genes					1.982	0.020	0.074	Up
Regulation of TP53 Activity through Methylation					−1.796	0.00	0.050	Down
Detoxification of Reactive Oxygen Species	1.522	0.041	0.280	Up
Interleukin-4 and Interleukin-13 signaling	2.109	0.024	0.152	Up	2.859	0.00	9.922	Up
Interleukin-10 signaling	1.748	0.036	0.201	Up