Table 1.
Baseline characteristics of the patients and respiratory mechanics (n = 16)
| Characteristics | |
| Male, n (%) | 11 (69) |
| Age (years) | 70 (61–72) |
| Body mass index (kg/m2) | 29 (26–31) |
| Organ failure at baseline (SOFA), n (%) | |
| Hemodynamic | 12 (75) |
| Renal | 4 (25) |
| Hepatic | 2 (13) |
| Hematological | 1 (6) |
| Arterial blood gas | |
| PaO2/FiO2 ratio | 170 (150–208) |
| pH | 7.43 (7.38–7.47) |
| PaO2 (mmHg) | 71 (62–89) |
| PaCO2 (mmHg) | 40 (37–45) |
| Lactates (mmol/l) | 1.2 (1–1.4) |
| Radiologic characteristics, n (%) | |
| Bilateral pneumonia | 4 (25) |
| Multiple mottling and ground-glass opacity | 12 (75) |
| Time between admission and intubation (day) | 2 (2–3) |
| Respiratory mechanics at day 1 | |
| Tidal volume (ml/kg PBW) | 7 (6.6–7.3) |
| Respiratory rate (beats/min) | 22 (20–24) |
| PEEPtot,rs (cm H2O) | 10 (10–13) |
| PEEPtot,es (cm H2O) | 8 (8–12) |
| PEEPtot,L (cm H2O) | 2 (−1–3) |
| Pplat,rs (cm H2O) | 19 (18–22) |
| Pplat,es (cm H2O) | 13 (11–16) |
| Pplat,L (cm H2O) | 6 (6–11) |
| DP,rs (cm H2O) | 9 (6–12) |
| DP,cw (cm H2O) | 5 (3–5) |
| DP,L (cm H2O) | 4 (2–9) |
| Est,rs (cm H2O/L) | 23 (18–30) |
| Est,cw (cm H2O/L) | 4 (4–10) |
| Est,L (cm H2O/L) | 19 (8–20) |
Results are expressed as median (IQR) or as number of patients (percentage) as appropriate
PBW, predicted body weight; SOFA, sepsis-related organ failure; PEEPtot,rs, static end-expiratory pressure of the respiratory system; PEEPtot,es, static end-expiratory esophageal pressure; PEEPtot,L, static end-expiratory transpulmonary pressure; Pplat,rs, static end-inspiratory pressure of the respiratory system; Pplat,es, static end-inspiratory esophageal pressure; Pplat,L, static end-inspiratory transpulmonary pressure; DP,rs, DP,cw, DP,L, driving pressure of respiratory system, chest wall, and lung, respectively; Est,rs, Est,cw, Est,L, static elastance of respiratory system, chest wall, and lung, respectively