Fig. 1.

Murray score and DPP3 levels in angiotensin II-treated ICU patients. Assessment of Murray score and dipeptidyl-peptidase 3 (DPP3) levels in COVID-19-positive ICU patients during angiotensin II treatment. The Murray score was calculated by scoring hypoxemia, respiratory system compliance, chest radiographic findings, and level of positive end-expiratory pressure. Each criterion receives a score from 0 to 4 according to the severity of the condition. The final score was obtained by dividing the collective score by the number of components that were used. A score of zero indicated no lung injury, a score of 1–2.5 indicated mild to moderate lung injury, and a final score of more than 2.5 indicated the presence of ARDS. DPP3 was assessed by measuring once daily 500 μl EDTA whole blood patient samples. DPP3 values below 40 ng/ml were considered as normal; DPP3 values above 40 ng/ml were associated with multi-organ failure and short-term death. Values above 150 ng/ml were depicted as 150 ng/ml and are valid. AT II, angiotensin II; DPP3, dipeptidyl-peptidase 3