Table 3.
HPMEC genes regulated by miR-887-3p with known relevance to ARDS
| Category | Gene | Fold Change | Adjusted P Value | Relevant Literature |
|---|---|---|---|---|
| Leukocyte trafficking | CXCL10 | 14.3 | <1 × 10−306 | CXCL10-CXCR3 interaction enhances neutrophil recruitment and lung injury (24) |
| CCL5 | 9.6 | <1 × 10−306 | CCL5 regulates neutrophil migration in experimental acute lung injury (37) | |
| CX3CL1 | 9.5 | 2.49 × 10−284 | Plasma CX3CL1 levels correlate with organ failure and mortality in sepsis (23) | |
| VCAM1 | 5.5 | <1 × 10−306 | Endothelial VCAM1 is elevated in ARDS and facilitates leukocyte trafficking (5) | |
| Endothelial activation/integrity | CASP1 | 5.1 | <1 × 10−306 | Inflammasome activation associated with human ARDS and worsening experimental acute lung injury (13) |
| IL1B | 5.7 | <1 × 10−306 | Inflammasome activation associated with human ARDS and worsening experimental acute lung injury (13) | |
| IFNB1 | 9.8 | 1.1 × 10−89 | Interferon-β1 associated with endothelial permeability and mortality in ARDS (9, 27) | |
| TLR2 | 6.3 | <1 × 10−306 | Toll-like receptor 2 stimulation enhances endothelial cell permeability (25) |
HPMEC, human pulmonary microvascular endothelial cells; ARDS, acute respiratory distress syndrome; CXCL10, C-X-C motif chemokine 10; CCL5, C-C motif chemokine ligand 5; CX3CL1, C-X3-C motif chemokine ligand 1; VCAM1, vascular cell adhesion molecule 1; CASP1, caspase 1; IL1B, interleukin-1β; IFNB1, interferon-β1; TLR2, Toll-like receptor 2.