Fig. 2.

Transcriptomic alterations in lungs after 3 days of hyperoxia and/or aurothioglucose (ATG) treatment. Newborn C57BL/6 mice were treated with saline (SAL) or 25 mg/kg ATG within 12 h of birth and exposed to room air (RA; 21% O₂) or hyperoxia (HYP; >95% O₂) for 72 h. RNA was isolated and purified from snap-frozen peripheral lungs, and RNA-sequencing analysis was performed. A: heat map and hierarchical clustering of upregulated (blue) and downregulated genes (red). B: principal component analysis (PCA) demonstrating segregation of groups (ovals).