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PTEN inhibitor improved the impaired epithelial regeneration-related signaling pathways in diabetic mice. Diabetic mice were topically applied with 10 µM bpv (Pic or Phen) 24 hours before epithelial debridement. After 48 hours of injury, mouse corneas were harvested for immunofluorescence staining (A) and Western blot (B; n = 3 per group) of p-Akt, p-Stat3, Sirt1, and Parkin. *P < 0.05.
