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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Oncogene. 2020 Jan 10;39(11):2243–2257. doi: 10.1038/s41388-020-1154-2

Fig. 2. Diagram of IGFBP2 functions in embryogenesis and tumorigenesis.

Fig. 2

IGFBP2 is predominantly expressed in fetal tissues that are highly proliferative, such as the early postimplantation epiblast and ventricular zone of rostral neuroepithelium, the apical ectodermal ridge, nascent astroglia, and the progenitors of spleen and liver cells. Aberrant expression of IGFBP2 is found in many types of human cancer and is implicated in multiple diverse oncogenic events.