. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: Oncogene. 2020 Jan 10;39(11):2243–2257. doi: 10.1038/s41388-020-1154-2

Table 1.

Overview of IGFBP2 domains.

Domains	Motifs	Sequence of motifs	Functions	References
N-terminal domain	IGF-binding site		IGF-I and -II binding	[81]
L-domain	NLS (also as HBD1)	¹⁷⁹pkklrp¹⁸⁴	GAG recognition, IGFBP2 nuclear translocation, Interaction with RPTPβ	[74, 91, 93, 97]
C-terminal domain	RGD	²⁶⁵rgd²⁶⁷	Interaction with IIp45 and Integrins	[99–101]
	HBD2	²²⁷khglynlkqckmslngqr²⁴⁴	Binding to GAGs in a pH-dependent manner	[79]
	IGF-binding site		IGF-I and -II binding	[81, 85]