Table 2.

IGFBP2 regulates tumorigenesis in multiple cancer types.

Cancer types	Potential pathway	Description	References
Glioma	integrin/ILK/NF-κB	Interacting with integrin and stimulating downstream ILK/NF-κB signaling	[68]
	EGFR/STAT3	Facilitating EGFR nuclear signaling accumulation to potentiate STAT3 transactivation activities	[73]
	integrin/FAK/β-catenin	Increasing nuclear activity of β-catenin via integrin/FAK induced inactivation of GSK3β	[105]
	integrin/ERK	Promoting ERK phosphorylation and nuclear translocation	[122]
	LSD1/H3K9 and H3K27	Decreasing the methylation level via upregulating LSD1	[126]
	FAK/ERK/SP1/CD144	Enhancing CD144 expression via the FAK/ERK/SP1 pathway	[151]
Breast cancer	PTEN/p21	Counteracting the antitumor effect by PTEN with an increase of p21	[102]
	β-catenin/Wnt	Activating the β-catenin/Wnt pathway to exert pro-tumorigenic function	[129]
	IGF-I/IGF-IR	Mediating endothelial recruitment through IGF-I/IGF-IR	[148]
Colorectal cancer	L1/ezrin/NF-kB	Mediated by the L1/ezrin/NF-kB network and contributes to tumorigensis	[30]
Pancreatic cancer	PTEN/Akt/IKKb/p65	Facilitating nuclear translocation of P65 in a PI3K/Akt/IKKb pathway dependent manner	[134]
Prostate cancer	hTERT, telomerase	Upregulating the expression of hTERT and activating the activation of telomerase	[70]
	MAPK, PI3K	Activating MAPK and PI3K signaling to conduct proliferation	[70]
	Integrin/PTEN	Interacting with integrin to increase the phosphorylation of PTEN	[136]