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. 2020 Feb 7;9(3):4. doi: 10.1167/tvst.9.3.4

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Figure 4. — VEGFR1 knockdown attenuated tumorigenicity in three-dimensional gels of collagen I in vitro. (A) The VM tube formation assay in MUM-2B cells of control (sh-ctrl) and VEGFR1 KD (sh-VEGFR1 1 and sh-VEGFR1 3). Images are representative examples from three separate experiments. (B) Quantification of vascular tube formation density. (n. 3). ^*P < 0.05. (C) Macroscopic appearance of control and VEGFR1-KD-treated melanoma dissected after 2 weeks of tumor growth. (D) Quantification of tumor volume (A). (n. 4). ^*P < 0.05.