Appendix 1—table 2. List of identified Streptomyces strains with homology to aco, avar1, and cyp genes involved in avenolide biosynthesis in S. avermitilis.
Strains are from the genus Streptomyces unless otherwise noted.
| Receptor | Aco | Cyp450 | Strain |
|---|---|---|---|
| ADK59_29015 | ADK59_RS28945 | ADK59_RS28935 | XY332 |
| ADK54_RS22575 | ADK54_RS22580 | ADK54_RS22570 | WM6378 |
| SPRI_RS01555 | SPRI_RS01560 | SPRI_RS01550 | S. pristinaespiralis |
| SPRI_RS34865/spbR | SPRI_RS34860 | SPRI_RS34870 | S. pristinaespiralis |
| AVL59_26260 | AVL59_RS26265 | AVL59_RS26255 | S. griseochromogenes strain ATCC 14511 |
| ASE41_15570/scaR | ASE41_RS08690 | ASE41_RS08700 | Streptomyces sp. Root264 |
| B446_03460 | B446_RS03395 | B446_RS03385 | S. collinus (strain DSM 40733/Tu 365) |
| SAZU_2710 | AOQ53_RS12925 | AOQ53_RS12915 | S. azureus strain ATCC 14921 |
| tylP | orf18 | orf16 | S. fradiae |
| TU94_00975 | TU94_RS00980 | TU94_RS00965 | S. cyaneogriseus subsp. noncyanogenus |
| AT728_21175 | AT728_RS06415 | AT728_RS06425 | S. silvensis |
| SSFG_07848 | SSFG_07849 | SSFG_07847 | S. viridosporus ATCC 14672 |
| AQJ91_00095 | AQJ91_RS00090 | AQJ91_RS00100 | RV15 |
| SGLAU_25540 | SGLAU_RS25200 | SGLAU_RS25210 | S. glaucescens |
| AQI88_17505 | AQI88_RS17500 | AQI88_RS17510 | S. cellostaticus |
| avaR1 | aco/SM007_06205 | cyp17 | S. avermitilis |
| BEN35_RS25960 | BEN35_RS25965 | BEN35_RS25955 | S. fradiae strain Olg4R |
| SGM_6044 | SGM_6045 | SGM_6043 | S. griseoaurantiacus M045 |
| AQJ66_RS29075 | AQJ66_29065 | AQJ66_RS29080 | S. bungoensis |
| BIV23_RS09990 | BIV23_RS09995 | BIV23_RS09985 | MUSC 1 |
| OP17_RS26145 | OP17_RS26140 | OP17_RS26150 | S. aureofaciens strain NRRL B-1286 |
| AOK23_RS06340 | AOK23_RS06335 | AOK23_RS06345 | S. torulosus strain NRRL B-3889 |
| AOK12_RS18690 | AOK12_RS18695 | AOK12_RS18685 | S. kanamyceticus strain NRRL B-2535 |
| AOK14_RS28840 | AOK14_RS28845 | AOK14_RS28835 | S. neyagawaensis strain NRRL B-3092 |
| JHAT_RS31450 | JHAT_RS31455 | JHAT_RS31445 | JHA26 |
| IG92_RS0101750 | IG92_RS0101755 | IG92_RS0101745 | S. cacaoi subsp. cacaoi NRRL S-1868 |
| IH57_RS0113175 | IH57_RS0113170 | IH57_RS0113180 | NRRL F-5053 |
| TR46_RS36115 | TR46_RS36110 | TR46_RS36120 | Streptacidiphilus carbonis strain NBRC 100919 |
| AWZ10_RS30605 | AWZ10_RS30600 | AWZ10_RS30610 | S. europaeiscabiei strain 96–14 |
| AMK31_RS05975 | AMK31_RS05980 | AMK31_RS05970 | TSRI0107 |
| OQI_RS18015 | OQI_RS18020 | OQI_RS18010 | S. pharetrae CZA14 |
| AOK15_RS33540 | AOK15_RS33545 | AOK15_RS33535 | S. ossamyceticus strain NRRL B-3822 |
| AOK17_RS00790 | AOK17_RS00795 | AOK17_RS00785 | S. phaeochromogenes strain NRRL B-1248 |
| B079_RS0125750 | B079_RS0125745 | B079_RS0125755 | LaPpAH-108 |
| AMK33_RS39295/AMK33_38290 | AMK33_RS39290 | AMK33_RS39300 | CB02400 |
| ASC56_RS07050 | ASC56_RS07055 | ASC56_RS07045 | TP-A0356 |
| BEK98_43205 | BEK98_43200 | BEK98_RS44190 | S. diastatochromogenes |
| SAMN04487983_101174 | SAMN04487983_101173 | SAMN04487983_101175 | yr375 |
| B5181_21375 | B5181_21380 | B5181_21370 | 4F |
| B9W62_10200 | B9W62_10205 | B9W62_10195 | CS113 |
| SAMN05216260_11022 | SAMN05216260_11023 | SAMN05216260_11021 | S. jietaisiensis |
| BN2145_RS03090 | BN2145_RS03095 | BN2145_RS03085 | S. leeuwenhoekii |
| KY5_6076 | KY5_6075 | KY5_6077 | S. formicae |
| CW362_40715/CW362_RS40740 | CW362_40710 | CW362_40720 | S. populi |
| SAMN05421806_12721 | SAMN05421806_12722 | SAMN05421806_12720 | S. indicus |
| CTU88_08915 | CTU88_08920 | CTU88_08910 | JV178 |
| BX282_0700 | BX282_0701 | BX282_0699 | 1121.2 |
| SAMN06272765_6800 | SAMN06272765_6799 | SAMN06272765_6801 | Ag109_G2-15 |
| CJD44_11095 | CJD44_11100 | CJD44_11090 | alain-838 |
| C3488_RS02995 | C3488_RS03000 | C3488_RS02990 | Ru72 |
| C6Y14_RS06395 | C6Y14_06390 | C6Y14_RS06400 | A217 |
| IF73_RS0131080 | IF73_RS0131075 | IF73_RS0131085 | NRRL F-5727 |
| C6N75_16870/C6N75_RS16880 | C6N75_16875 | C6N75_RS16865 | ST5x |
| VO63_07870 | VO63_07865 | VO63_07875 | S. showdoensis |
| IF54_RS0133395 | IF54_RS0133390 | IF54_RS0133400 | NRRL B-3229 |
| EW58_RS46355 | EW58_RS46360 | EW58_RS46350 | S. mirabilis |
| BG482_RS07255 | BG482_RS07260 | BG482_RS07250 | LUP30 |
| STEPF7_RS00065 | STEPF7_RS00060 | STEPF7_RS00070 | F-7 |
| C6376_26350 | C6376_26345 | C6376_26355 | P3 |
| BS75_RS38740 | BS75_RS38735 | BS75_RS38745 | Streptacidiphilus albus JL83 |
| SMA5143A_3910 | SMA5143A_3909 | SMA5143A_3911 | MA5143a |
| SLUN_38640 | SLUN_38645 | SLUN_38635 | S. lunaelactis |
| CLW08_6960/CLW08_RS34500 | CLW08_6959 | CLW08_6961 | 69 |
| CLW15_0573 | CLW15_0574 | CLW15_0572 | 73 |
| DC095_032510 | DC095_032505 | DC095_032515 | S. xinghaiensis |
| C8R36_7975 | C8R36_7974 | C8R36_7976 | 3212.5 |
| CLW07_7979 | CLW07_7978 | CLW07_7980 | 67 |
| BX279_8804 | BX279_8803 | BX279_8805 | Ag82_O1-9 |
| C8R37_8029 | C8R37_8028 | C8R37_8030 | 3212.4 |
| DT_019_27550 | DT_019_27545 | DT_019_27555 | SDr-06 |
| EDD87_5077 | EDD87_5076 | EDD87_5078 | S. ossamyceticus |
| C4J65_35580 | C4J65_35585 | C4J65_35575 | CB09001 |
| DI272_14555 | DI272_14560 | DI272_14550 | Act143 |
| DKG34_25265 | DKG34_25260 | DKG34_25270 | NWU49 |
| CLW14_9027 | CLW14_9026 | CLW14_9028 | 75 |
| EDE03_1306 | EDE03_1307 | EDE03_1305 | Ag82_G5-5 |
| E2B92_31970 | E2B92_31965 | E2B92_31975 | WAC05374 |
| FE633_RS10505 | FE633_RS10500 | FE633_RS10510 | NEAU-C151 |
| FGD71_RS00515 | FGD71_RS00510 | FGD71_RS00520 | NEAU-SSA 1 |
| FNX44_RS06285 | FNX44_RS06290 | FNX44_RS06280 | OF1 |
| E4K73_RS21075 | E4K73_RS21070 | E4K73_RS21080 | IB201691-2A2 |
| EV585_RS00830 | EV585_RS00825 | EV585_RS00835 | BK335 |
| EV288_RS22310 | EV288_RS22315 | EV288_RS22305 | BK215 |
| DN402_06475 | DN402_06480 | DN402_06470 | SW4 |
| F3T56_RS11975 | F3T56_RS11980 | F3T56_RS11970 | TRM68348 |
| EV298_RS42585 | EV298_RS42590 | EV298_RS42580 | BK042 |
| ESG85_RS18290 | ESG85_RS18295 | ESG85_RS18285 | TRM44457 |
| EV588_RS28855 | EV588_RS28860 | EV588_RS28850 | BK141 |
| B9W62_10200 | B9W62_10205 | B9W62_10195 | CS113 |
| FB157_RS34410 | FB157_RS34405 | FB157_RS34415 | BK340 |
| TNCT1_RS20710 | TNCT1_RS20705 | TNCT1_RS20715 | 1–11 |
| Sri02f_RS33870 | Sri02f_RS33865 | Sri02f_RS33875 | S. rishiriensis strain NBRC 13407 |