TABLE 3.

Relationship between enteral nutrition type (breast milk versus formula) and white matter microstructural development

	Fractional Anisotropy			Mean Diffusivity (× 10−3 mm2/seconds)
Region of Interest	Breast Milk (n = 42) Mean (95% CI)	Formula (n = 23) Mean (95% CI)	P valuea	Breast Milk (n = 42) Mean (95% CI)	Formula (n = 23) Mean (95% CI)	P valuea
CC	0.55 (0.53-0.58)	0.54 (0.51-0.57)	.53	1.28 (1.23-1.33)	1.38 (1.31-1.45)	.03
Left PLIC	0.59 (0.58-0.61)	0.58 (0.56-0.60)	.21	0.92 (0.90-0.95)	0.99 (0.96-1.02)	<.01
Right PLIC	0.60 (0.58-0.61)	0.58 (0.56-0.60)	.26	0.94 (0.92-0.96)	0.98 (0.95-1.02)	.03
MCP	0.51 (0.47-0.54)	0.52 (0.48-0.56)	.83	0.80 (0.77-0.83)	0.86 (0.82-0.90)	.02
SCP	0.37 (0.35-0.38)	0.36 (0.34-0.38)	.56	0.86 (0.84-0.88)	0.88 (0.86-0.91)	.21
Vermis	0.19 (0.18-0.20)	0.23 (0.21-0.24)	<.01	0.71 (0.68-0.74)	0.73 (0.69-0.77)	.56
Pons	0.39 (0.37-0.40)	0.39 (0.37-0.42)	.69	0.84 (0.81-0.86)	0.84 (0.81-0.87)	.85

Abbreviations: CC, corpus callosum; MCP, middle cerebellar peduncle; PLIC, posterior limb of internal capsule; SCP, superior cerebellar peduncle.

^aBased on least squares means estimates from generalised linear models adjusted for gestational at birth and postmenstrual age at MRI.