Table 1.
Detailed Information for the Associations of miR-125a with Various Lung Diseases
| Lung Diseases | Evidence | PubMed Identifier (PMID) |
|---|---|---|
| Lung neoplasms | the results demonstrated that the panel of miRNA biomarkers (miR-125a-5p, miR-25, and miR-126) had the potential for the early detection of lung cancer; | 25639977 |
| Non-small-cell lung carcinoma | these preliminary data suggest that serum miR-125a-5p, miR-145, and miR-146a may be useful noninvasive biomarkers for the clinical diagnosis of non-small-cell lung cancer | 25755772 |
| Lung neoplasms | our results provide compelling evidence that miR-125a-5p, an epidermal growth factor-signaling-regulated miRNA, may function as a metastatic suppressor | 19702827 |
| Non-small-cell lung carcinoma | hsa-miR-125a-5p was poorly expressed in lung cancer cells, and it could enhance lung cancer cell invasion by upregulating hsa-miR-125a-5p | 20719190 |
| Lung neoplasms | miRNA hsa-miR-125a-3p activates p53 and induces apoptosis in lung cancer cells | 24044511 |
| Non-small-cell lung carcinoma | hsa-miR-125a-5p could upregulate Rock-1 and enhance invasion in lung cancer cells | 20723344 |
| Small-cell lung carcinoma | chemotherapy-regulated miRNA-125-HER2 pathway as a novel therapeutic target for trastuzumab-mediated cellular cytotoxicity in small-cell lung cancer | 25833836 |
| Non-small-cell lung carcinoma | miR-125a-3p targets MTA1 to suppress non-small-cell lung cancer cell proliferation, migration, and invasion | 25998575 |
| Lung carcinoma | miRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3 | 28631574 |
| Non-small-cell lung carcinoma | miR-125a-3p:Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small-cell lung cancer | 20569443 |
| Non-small-cell lung carcinoma | we showed that, compared to adjacent non-neoplastic lung tissues, the expressions of miR-125a-5p and let-7e were decreased in lung adenocarcinomas and squamous-cell lung carcinomas samples | 22618509 |
| Non-small-cell lung carcinoma | differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small-cell lung cancer | 24945821 |
| Lung carcinoma | miRNA expression profiles of granulocytic myeloid-derived suppressor cells from mice bearing Lewis lung carcinoma | 27748875 |