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HLA-DR expression is lower in CRC carcinomas compared to carcinoma–adjacent tissue, but only in the stromal compartment. HLA-DR expression was higher in the stroma of carcinoma–adjacent tissues compared to matched carcinomas, for both early-stage a (p < 0.001, n = 76) and late-stage b (p < 0.001, n = 72) CRC cases, whereas no statistically significant difference was detected within the epithelium, regardless of stage. Wilcoxon matched paired t tests; bars denote mean ± SEM. ***p < 0.001
