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. 2020 Apr 18;69(8):1577–1588. doi: 10.1007/s00262-020-02571-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — HLA-DR expression is associated with longer overall survival when measured in carcinoma–adjacent epithelium and stroma, but not in carcinoma compartments. A cohort of n = 77 stage II CRC patient specimens were segregated into HLA-DR high or low populations based on median expression level, and differences in survival time were assessed by log rank (Mantel–Cox) test, in tissue epithelium and stroma. The HLA-DR^high cohort showed a longer survival time compared to HLA-DR^low populations, in carcinoma–adjacent normal colorectal epithelium (a) and stroma (b), but no difference was observed within the carcinoma epithelium (c) or stroma (d)