Fig. 3.

a Biosynthesis of desferrioxamine B and its iron chelation product ferrioxamine. b First, the pyridoxal phosphate (PLP)–dependent decarboxylase (DC) provides the substrate for the flavin N-hydroxylase (NMO), which activates molecular oxygen via reduced FAD. Then, activated acyl or succinyl residues are transferred to provide the substrate for the NRPS-independent ATP utilizing synthetase (NIS). b Biosynthesis of albachelin. A flavin-dependent N-hydroxylase (AMO) catalyzes the production of N⁵-hydroxyornithine, multiple subsequent steps follow. c Malleobactins are synthesized by the pathogenic bacterium Burkholderia pseudomallei in which the activity of the NMO MbaC leads to four different siderophore structures