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. 2020 Jul 9;10:11344. doi: 10.1038/s41598-020-68226-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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67% of chronic patients had detectable HBV-specific T cells ex vivo. (A) Schematic of the optimized peptide pulsing and ELIspot plating strategy. The same peptide pulsing and plating strategy was used for the Fluorospot assay and single OLP pool stimulations to determine antigen-specificity (i.e. Figs. 1D, 6B). (B) Absolute SFU and (C) S:N ratios of 15 vaccinated donors tested with ex vivo IFN-γ ELISpot. (D) Absolute SFU and (E) S:N ratios of 30 CHB patients. To the left of the vertical dotted lines are non-responders. To the right are ELISpot-positive responders. Horizontal dotted lines indicate the positive S:N ratio threshold of 2.