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. 2020 Jul 9;10:11319. doi: 10.1038/s41598-020-68241-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of prodromal PD (1) and control ECGs (0) based on PSPR features. Note that PSPR features represent how a given ECG (from prodromal PD subjects or control) differs (dissimilarity or distant) from the ECGs of subjects with prevalent PD. This implies that the dissimilarity between ECGs of prodromal PD and prevalent PD are smaller (more similar) than the dissimilarity between controls and prevalent PD ECGs (less similar).