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. 2020 Jul 9;9(7):66. doi: 10.1038/s41389-020-00250-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Defining features of the CMS (top) and CRIS (bottom) subtypes are summarised in the respective tables. The relationship between classification systems is illustrated by the Sankey diagram in the middle. A total of 119 established cell lines (N = 91) and primary cell and organoid cultures (N = 28) could be assigned with high confidence using both classifiers^89,90. Colours of nodes correspond to the respective CMS and CRIS subtypes in the tables, size of the nodes reflects the number of cultures adhering to that particular subtype. For comparison with patient CMS–CRIS distribution, please refer to the publication of Isella et al.⁸⁹.