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. 2020 Jul 9;10:11316. doi: 10.1038/s41598-020-68172-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RA regulates her9 expression but Her9 is not required for the effects of RA on opsin expression. WISH for her9 expression at 36 hpf in control treated (A), DEAB treated (A′) and RA treated (A″) retinas. (B) qPCR for her9 expression in heads of 36 hpf zebrafish embryos following drug treatments. N = 20 heads per biological replicate, 3 biological replicates per drug treatment. *p < 0.05. GFP expression in control treated versus RA-treated XOPs:GFP; her9^+/+ (C–C′″) or XOPs:GFP; her9^−/− (D–D′″) retinas. (E) Cell counts comparing rhodopsin expressing cells in the untreated and treated retinas. (F–F′″) IHC for UV opsin in control versus RA-treated TαC:GFP; her9^+/+ (F–F′″) or TαC:GFP; her9^−/− (G–G′″) retinas. (H) Cell counts comparing UV opsin expressing cells in the untreated and treated retinas (# of opsin+/100 µm). CF, choroid fissure; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer; L, lens; Scale bar = 50 µm.