Fig. 4. AdC68–CR9114 protected mice from the different subtypes of influenza infection.

Mice were intravenously administered 5 × 10¹⁰ vp AdC68–CR9114 or 5 × 10¹⁰ vp AdC68–empty, and 24 h post administration, they were challenged with 10LD50 of the different subtypes of influenza virus, PR8 (A/Puerto Rico/8/34), H3N1 (A/Archi/1/1968), H5N1 (A/environment/Hunan/6-69/2008), and H9N2 (A/chicken/Jiangsu/7/2002). Body weight and survival rate were monitored for 14 days. a, c, e, g Body weight loss after challenge with PR8, H3N1, H5N1, and H9N2, respectively. Data are expressed as mean ± SD. b, d, f, h Survival rate after challenge with PR8, H3N1, H5N1, and H9N2, respectively. Five mice in each group.