Table 2.
LDC–PLC permeation tests from films through porcine buccal mucosa.
| LA | Film | Flux (µg cm−2 h−1) | Paap (cm h−1) × 10–3 | Lag time (h) |
|---|---|---|---|---|
| Lidocaine | PCT/LDC–PLC | 56.53 ± 13.63 | 2.26 ± 0.55 | 1.82 ± 1.06 |
| PCT/NLC | 108.76 ± 37.72* | 4.35 ± 1.51* | 2.05 ± 5.07 | |
| Prilocaine | PCT/LDC–PLC | 49.96 ± 23.48 | 1.99 ± 0.94 | 2.15 ± 1.14 |
| PCT/NLC | 89.73 ± 39.40* | 3.76 ± 1.70* | 0.00 ± 5.84* |
Steady-state flux (µg cm−2 h−1), apparent permeability coefficient (Paap; cm.h-1 × 10–3) and lag time (h) were quantified by HPLC. Data are mean (± SD), n = 6 (p < 0.05, t test). Each parameter was evaluated separately for each anesthetic.
t test. *Indicate significant statistical difference (p < 0.05) between control and hybrid batches.