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. 2020 Jul 9;10:11302. doi: 10.1038/s41598-020-68357-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of the LSPR-Nanosensor capability to distinguish DENV from ZIKV infections. Human Dengue virus-positive sera (DENV—red lines) and Zika virus-positive sera (ZKV—blue lines) were pooled and diluted in 1:10,000 ratios. Pools were individually added to each sensor GNR-DENV1E (A,B); GNR-DENV2E (C,D); GNR-DENV3E (E,F) or GNR-DENV4E (G,H). Flavivirus-negative pooled sera were used as controls (black lines). Reads were obtained between 700 and 950 nm wavelength range (graphs in A,C,E,G). Relative shifts on the region of zero of the derivative curves for each serum are shown below each graph (graphs in B,D,F,H). The equipment wavelength accuracy is ± 3 nm and shifts equal or higher than 5 nm were considered significant. Shifts are related to the sensor added with dengue-negative sera (DENVE-NEG sera). Samples from the sera bank depicted on Table S2 (supplementary material) were used in this experiment.