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. 2020 Jul 9;10:11328. doi: 10.1038/s41598-020-68077-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Univariate and multivariate linear regression model. Values are coefficient 95% confidence intervals. Unit of measurements of some biomarkers (serum C1,2C, COMP, CTXI and urinary CTXII, C1,2C, Coll2-1 NO2, CTXII alpha and beta) were adjusted to the power of 10, 100, 1,000 and logarithmically transformed. Biomarkers are considered as a group in the multivariate regression model and adjusted for age, BMI, gender and race.