Table 2.
Univariate and multivariate linear regression for JSW, KOOS pain and symptoms.
| Univariate | ||||||
|---|---|---|---|---|---|---|
| Biomarkers (n = 300–600) | JSW | KOOS pain | KOOS symptoms | |||
| Coeffecient (95% CI) | p value | Coefficient (95% CI) | p value | Coefficient (95% CI) | p value | |
| Serum C1,2C | − 0.0002 (− 0.0070, 0.0066) | 0.960 | 0.0079 (− 0.0634, 0.0791) | 0.828 | 0.015 (− 0.0469, 0.077) | 0.634 |
| Serum C2C | − 0.0016 (− 0.0036, 0.0004) | 0.116 | − 0.0101 (− 0.0314, 0.0112) | 0.353 | − 0.0009 (− 0.0195, 0.0176) | 0.922 |
| Serum CPII | 0.00013 (− 0.0001, 0.0005) | 0.393 | − 0.001 (− 0.0043, 0.0022) | 0.539 | − 0.0004 (− 0.0033, 0.0024) | 0.769 |
| Serum PIIANP | − 0.00001 (− 0.0002, 0.00013) | 0.920 | − 0.001 (− 0.0024, 0.0004) | 0.148 | − 0.0005 (− 0.0017, 0.0007) | 0.422 |
| Serum Coll2-1 NO2 | − 0.00474 (− 0.0237, 0.0143) | 0.624 | − 0.1811 (− 0.3796, 0.0173) | 0.074 | − 0·1424 (− 0.315, 0.0303) | 0.106 |
| Serum CS846 | − 0.00025 (− 0.0021, 0.0016) | 0.786 | − 0.0,104 (− 0.0294, 0.0086) | 0.283 | − 0.0138 (− 0.0303, 0.0028) | 0.102 |
| Serum MMP3 | − 0.00282 (− 0.0106, 0.0049) | 0.473 | 0.0572 (− 0.0236, 0.1379) | 0.165 | 0.0917 (0.0217, 0.1617) | 0.010 |
| Serum CTXI | 0.00006 (− 0.0004, 0.00055) | 0.787 | 0.0022 (− 0.0029, 0.0072) | 0.399 | 0.0004 (− 0.004, 0.0048) | 0.852 |
| Serum COMP | − 0.00189 (− 0.0360, 0.0322) | 0.913 | 0.0,013 (− 0.0023, 0.0049) | 0.480 | 0.0001 (− 0.003, 0.0032) | 0.943 |
| Serum HA | − 0.00543 (− 0.0082, − 0.0026) | 0.001 | − 0.0032 (− 0.0328, 0.0263) | 0.830 | 0.0113 (− 0.0142, 0.0369) | 0.385 |
| Serum NTXI | 0.01034 (− 0.0089, 0.0296) | 0.292 | 0.0386 (− 0.1632, 0.2405) | 0.707 | − 0.0292 (− 0·2047, 0·1463) | 0.744 |
| Urine CTXII | − 0.0105 (− 0.0157, − 0.0052) | 0.001 | − 0.0678 (− 0.1235, − 0.0120) | 0.017 | − 0.0730(− 0·1213, − 0.0247) | 0.003 |
| Urine C1,2C | 0.08211 (− 0.0084, 0.1726) | 0.075 | − 0.5382 (− 1.4914, 0.4151) | 0.268 | − 0·1075 (− 0·9360,0·7210) | 0.799 |
| Urine C2C | − 0.00143 (− 0.0024, − 0.0005) | 0.004 | 0.0025 (− 0.0077, 0.0128) | 0.627 | − 0.0006 (− 0.0095, 0.0083) | 0.889 |
| Urine NTXI | − 0.0006 (− 0.0065, 0.0053) | 0.837 | 0.0083 (− 0.0538, 0.0705) | 0.792 | 0.004 (− 0.0499, 0.058) | 0.884 |
| Urine CTX1 alpha | − 0.0001 (− 0.0003, 0.00023) | 0.742 | 0.0015 (− 0.0015, 0.0045) | 0.325 | 0.0009 (− 0.0017, 0.0035) | 0.501 |
| Urine CTX1 beta | 0.00001 (− 0.00004, 0.00008) | 0.579 | − 0.0001 (− 0.0007, 0.0006) | 0.837 | − 0.0001 (− 0.0006, 0.0005) | 0.761 |
| Urine Coll2-1 NO2 | 0.00023 (− 0.0085, 0.00901) | 0.958 | − 0.0422 (− 0.1405, 0.0561) | 0.399 | 0.0224 (− 0.063, 0·1077) | 0.607 |
| Urine creatinine | 0.01372 (− 0.0055, 0.0329) | 0.161 | − 0.18 (− 0.382, 0.022) | 0.081 | − 0.1414 (− 0·3169, 0.034) | 0.114 |
| Multivariate | ||||||
|---|---|---|---|---|---|---|
| Biomarkers (n = 580) | JSW | KOOS pain | KOOS symptoms | |||
| Serum C1,2C | 0.0032 (− 0.0052, 0.0116) | 0.456 | 0.0506 (− 0.0361, 0·1372) | 0.252 | 0.0387 (− 0.0367, 0.1141) | 0.314 |
| Serum C2C | − 0.0029 (− 0.0054, − 0.0004) | 0.023 | 0.0054 (− 0.0205, 0.0314) | 0.681 | 0.0146 (− 0.008, 0.0372) | 0.205 |
| Serum CPII | 0.0005 (0.000, 0.0009) | 0.033 | 0.0012 (− 0.0031, 0.0055) | 0.597 | 0.0014 (− 0.0024, 0.0,051) | 0.468 |
| Serum PIIANP | − 0.0001 (− 0.0002, 0.0001) | 0.788 | − 0.0005 (− 0.002, 0.0009) | 0.466 | − 0.0003 (− 0.0015, 0.001) | 0.658 |
| Serum Coll2-1 NO2 | − 0.0102 (− 0.0337, 0.0133) | 0.394 | − 0·1316 (− 0·3743, 0·1112) | 0.287 | − 0·1461 (− 0·3575, 0.0652) | 0.175 |
| Serum CS846 | − 0.0004 (− 0.0022, 0.0015) | 0.695 | − 0.0072 (− 0.0264, 0.0119) | 0.459 | − 0.0105 (− 0.0271, 0.0062) | 0.218 |
| Serum MMP3 | − 0.0027 (− 0.0116, 0.0063) | 0.559 | 0.0184 (− 0.0739, 0·1106) | 0.696 | 0.0594 (− 0.0209, 0.1397) | 0.147 |
| Serum CTXI | 0.0003 (− 0.0005, 0.0012) | 0.415 | 0.0034 (− 0.0052, 0.012) | 0.438 | 0.001 (− 0.0065, 0.0085) | 0.789 |
| Serum COMP | 0.0004 (0.0000, 0.0007) | 0.049 | 0.0015 (− 0.0023, 0.0053) | 0.437 | − 0.0007 (− 0.004, 0.0026) | 0.665 |
| Serum HA | − 0.0041 (− 0.0073, − 0.0009) | 0.013 | − 0.0017 (− 0.0349, 0.0314) | 0.919 | 0.0057 (− 0.0232, 0.0345) | 0.700 |
| Urine CTXII | − 0.0122 (− 0.0185, − 0.0058) | 0.001 | − 0.0862 (− 0.1517, − 0.0206) | 0.010 | − 0.0908 (− 0.1478, − 0.0337) | 0.002 |
| Urine C1,2C | 0.0892 (− 0.0184, 0·1968) | 0.104 | − 0.0164 (− 1.1282, 1.0953) | 0.977 | 0·3362 (− 0.6317, 1.3041) | 0.495 |
| Urine NTXI | 0.0011 (− 0.0098, 0.0119) | 0.848 | − 0.0016 (− 0.1133, 0.1101) | 0.977 | 0.0294 (− 0.0679, 0.1267) | 0.553 |
| Urine creatinine | 0.0012 (− 0.0239, 0.0263) | 0.925 | − 0·1347 (− 0.3937, 0.1243) | 0.307 | − 0·1139 (− 0.3394, 0.1115) | 0.321 |
Biomarkers are considered as a group in the multivariate regression model and adjusted for age, BMI, gender and race. Unit of measurements of some biomarkers (serum C1,2C, COMP, CTXI and urinary CTXII, C1,2C, Coll2-1 NO2, CTXII alpha and beta) were adjusted to the power of 10, 100, 1,000 and logarithmically transformed.
Statistically significant data are shown in bold.