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. 2020 Jul 9;10:11279. doi: 10.1038/s41598-020-67790-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dysregulation of microRNAs in heart failure. (a) 44 microRNAs that changed significantly in the sinus node in heart failure. The expression of each microRNA in heart failure mice is shown as a percentage of expression in control mice. The dotted line shows the control level. Based on data from 8 control and 10 heart failure mice. miR-370-3p is highlighted. (b) Expression of miR-370-3p in the sinus node (n = 7, 7 and 8) and ventricular muscle (n = 8, 9 and 7) of control mice given PBS, heart failure mice given PBS and heart failure mice given antimiR-370-3p. *P < 0.05; one-way ANOVA followed by Tukey’s multiple comparisons test. (c) Expression of miR-370-3p in the sinus node of control and heart failure patients (n = 3 and 5). *P < 0.05; after adjusting for effects of other factors and normalising differences between experiments, the General Linear Model was used to evaluate differences in miR-370-3p levels between control and failing human hearts.