Duplicates removed	122
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	40
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	107
Cited efficacy/tolerability articles	22
Cited articles not efficacy/tolerability	34
Search Strategy: EMBASE, MEDLINE and PubMed from 2017 to present. Previous Adis Drug Evaluation published in 2017 was hand-searched for relevant data. Clinical trial registries/databases and websites were also searched for relevant data. Key words were liposomal irinotecan, Onivyde, pancreatic cancer. Records were limited to those in English language. Searches last updated 4 Jun 2020