Table 2.

Model parameters

Model parameter	Baseline	Deterministic			Probabilistic		Source(s)
		Low	High		Alpha	Beta
Costs per cycle and state
Depressed (untreated)	106.25
Pharmaceutical	6.71	4.70	8.98	Gamma	0.51	13.26	[79, 81]
Outpatient	11.75	9.76	13.92	Gamma	1.55	7.58	[79, 81]
Inpatient	48.65	18.12	83.70	Gamma	0.11	434.58	[79, 81]
Indirect	39.14	15.28	73.87	Gamma	0.09	425.60	[79, 81]
Depressed (during CBT)	57.60
Pharmaceutical	6.71	4.70	8.98	Gamma	0.51	13.26	[79, 81]
Outpatient	11.75	9.76	13.92	Gamma	1.55	7.58	[79, 81]
Indirect	39.14	15.28	73.87	Gamma	0.09	425.60	[79, 81]
Remission	9.23
Pharmaceutical	3.35	2.35	4.49	Gamma	0.51	6.63	[79, 81]
Outpatient	5.88	4.88	6.96	Gamma	1.55	3.79	[79, 81]
Treatment costs
FCBT (total)	1303.22
ICBT (total)	736.90
First appointment (to week 1)	44.33						[82]
Evaluation sessions (n = 3)	196.17	130.78	261.56				[82]
Software (ICBT only)	50.00	25.00	100.00				[28, 35]
FCBT (per week)	88.56						[83]
ICBT (per week)	37.20	7.08	67.31	Gamma	1.53	24.38	[68, 83]
QoL by state
Remission	0.85	0.72	0.98	Beta	54,640	9642	[77]
Depressed (untreated)	0.29
Mild	0.45	0.23	0.67	Beta	1996	2440	[77]
Moderate	0.33	0.09	0.57	Beta	3804	7723	[77]
Severe	0.15	0.00	0.36	Beta	344	1949	[77]
Depressed (during CBT)	0.47
Mild	0.74	0.55	0.93	Beta	4588	1612	[77]
Moderate	0.44	0.17	0.71	Beta	3529	4491	[77]
Severe	0.30	0.03	0.57	Beta	415	967	[77]
Death	0.00
Discount rate	0.03	0.00	0.06				[49]
Transition probabilities
FCBT → REM	0.6090	0.5311	0.6870	Beta	91.13	58.50	[39–45, 60–62]
ICBT → REM	0.5174	0.3878	0.6470	Beta	29.04	27.09	[63–69]
FCBT → Drop out	0.0145	0.0054	0.0236	Beta	9.64	655.64	[39–45, 60–62]
ICBT → Drop out	0.0201	0.0132	0.0270	Beta	31.77	1546.96	[63–69]
DPR → sp. REM	0.0123	0.0018	0.0227	Beta	5.25	422.56	[42, 63–67, 71, 72]
REM → DPR	0.0064	− 0.0035	0.0164	Beta	1.59	245.61	[39–47]
Sp. REM → DPR	0.0202	− 0.0200	0.0604	Beta	0.93	45.07	[48]
All-cause death	3.29E−05						[73, 74]

DPR depressed, Drop-out treatment discontinuation, FCBT face-to-face cognitive behavioral therapy, ICBT internet-based cognitive behavioral therapy, QoL quality of life, REM remission, sp. REM spontaneous remission